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Article

Transcriptional regulation of theTGF-β1promoter by androgen receptor

25 Jul 2008

Abstract excerpt

TGF (transforming growth factor)-beta1 is a multifunctional cytokine that influences homoeostatic processes of various tissues. TGF-beta1 expression is inhibited by androgens in the prostate gland, whereas its expression is enhanced by androgens in highly metastatic prostate cancer cells. Here, we examined regulation of human TGF-beta1 promoter activity by androgen in prostate cancer cells. The full-length (-3363...

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Share to Estrogen and related hormone effects
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PMID: 18651839
DOI: 10.1042/bj20080651

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