Article
Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test.
Diabetes - 1 Nov 2008
Qi Lu, Kang Kihwa, Zhang Cuilin, van Dam Rob M, Kraft Peter, Hunter David, Lee Chih-Hao, Hu Frank B
Abstract excerpt
OBJECTIVE: To examine the longitudinal association of fat mass-and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse. RESEARCH DESIGN AND METHODS: We genotyped rs9939609 in 2,287 men and 3,520 women from two prospective cohorts. Plasma adiponectin and leptin were measured in a subset of diabetic men (n = 854) and women (n =...
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