Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD).

Clinical endocrinology - 1 Sept 2008

Tadjine Mimi, Lampron Antoine, Ouadi Lydia, Horvath Anelia, Stratakis Constantine A, Bourdeau Isabelle

Abstract excerpt

BACKGROUND: Primary pigmented nodular adrenocortical disease (PPNAD) leads to Cushing syndrome (CS) and is often associated with Carney complex (CNC). Genetic alterations of the type 1-alpha regulatory subunit of cAMP-dependent protein kinase A (PRKAR1A) and phosphodiesterase 11A4 (PDE11A) genes have been found in PPNAD. Recent studies have demonstrated that beta-catenin mutations are frequent in adrenocortical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3',5'-Cyclic-GMP Phosphodiesterases
Share to Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adrenal Cortex Neoplasms

Share to beta Catenin

Share to Cyclic AMP-Dependent Protein Kinase RIalpha Subunit

Share to Genetic Testing

Share to Phosphoric Diester Hydrolases

Share to Pigmentation Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 18419788
DOI: 10.1111/j.1365-2265.2008.03273.x
PMCID: PMC3138207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD).PMID 18419788Read ↗

PRKAR1A mutations in primary pigmented nodular adrenocortical disease.Semantic proximity Read ↗

Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease.Semantic proximity Read ↗

Primary pigmented nodular adrenocortical disease (PPNAD): single centre experienceSemantic proximity Read ↗

Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors.Semantic proximity Read ↗

Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease, and other corticotropin-independent lesions.Semantic proximity Read ↗

Children with Cushing's syndrome: Primary Pigmented Nodular Adrenocortical Disease should always be suspected.Semantic proximity Read ↗

Molecular Basis of Primary Aldosteronism and Adrenal Cushing SyndromeSemantic proximity Read ↗

Genetic Alterations in Benign Adrenal TumorsSemantic proximity Read ↗

Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.Semantic proximity Read ↗

Integrated clinical-genetic-pathological analysis expands the phenotypic and molecular spectrum of PPNAD across carney complex and isolated forms.Semantic proximity Read ↗

A Novel Mutation in the type Iα Regulatory Subunit of Protein Kinase A (PRKAR1A) in a Cushing's Syndrome Patient with Primary Pigmented Nodular Adrenocortical Disease.Semantic proximity Read ↗

Molecular Genetic and Genomic Alterations in Cushing’s Syndrome and Primary AldosteronismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.