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Article

Capsular polysaccharide induction of apoptosis by intrinsic and extrinsic mechanisms

8 Jul 2008

Abstract excerpt

A purified microbial capsular polysaccharide of Cryptococcus neoformans, glucuronoxylomannan (GXM), induces Fas ligand (FasL) upregulation on macrophages and, as a consequence, apoptosis of lymphocytes. The mechanisms that lead to lymphocyte apoptosis in both in vitro and in vivo systems were investigated by cytofluorimetric analysis and Western blotting experiments. Caspase 8 cleaves caspase 3 in two different...

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PMID: 18647312
DOI: 10.1111/j.1462-5822.2008.01196.x

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