Article
DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2008
Chattergoon Michael A, Muthumani Karuppiah, Tamura Yutaka, Ramanathan Mathura, Shames Jason P, Saulino Vera, Robinson Tara M, Montaner Luis J, Weiner David B
Abstract excerpt
Non-homeostatic tissue apoptosis in vivo has been shown to induce inflammatory responses and facilitate the cross-presentation of proteins within apoptotic bodies. We hypothesize that in the presence of foreign antigens, the apoptotic-inflammatory process improves immune priming; further, molecules that trigger apoptosis may be adapted for use as immune adjuvants. One very attractive molecule in this context is...
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