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Article

Virological fitness of HIV in patients with resistance to enfuvirtide.

AIDS (London, England) - 12 Sept 2007

Chibo Doris, Roth Norman, Roulet Vanessa, Skrabal Katharina, Gooey Megan, Carolan Louise, Nicholls Jodie, Papadakis Anastasia, Birch Chris

Abstract excerpt

Resistance to the HIV fusion inhibitor enfuvirtide is associated with mutations in the first heptad repeat region of gp41, but little is known of their impact on replicative fitness in vivo. We followed seven patients undergoing salvage therapy that included enfuvirtide in order to document the temporal generation of genotypic and phenotypic resistance in parallel with replicative fitness. Resistance to...

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Share to Antiretroviral Therapy, Highly Active
Share to CD4 Lymphocyte Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HIV Envelope Protein gp41

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Identifiers

PMID: 17721108
DOI: 10.1097/QAD.0b013e3282ef1bc8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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