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Article

Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells.

The Journal of cell biology - 28 Jul 2008

Lombardi Maria, Castoria Gabriella, Migliaccio Antimo, Barone Maria Vittoria, Di Stasio Rosina, Ciociola Alessandra, Bottero Daniela, Yamaguchi Hiroshi, Appella Ettore, Auricchio Ferdinando

Abstract excerpt

In breast cancer cells, cytoplasmic localization of the estradiol receptor alpha (ERalpha) regulates estradiol-dependent S phase entry. We identified a nuclear export sequence (NES) in ERalpha and show that its export is dependent on both estradiol-mediated phosphatidylinositol-3-kinase (PI3K)/AKT activation and chromosome region maintenance 1 (CRM1). A Tat peptide containing the ERalpha NES disrupts ERalpha-CRM1...

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Identifiers

PMID: 18644889
DOI: 10.1083/jcb.200712125
PMCID: PMC2483513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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