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Article

NTF-3, a gene involved in the enteric nervous system development, as a candidate gene for Hirschsprung disease.

Journal of pediatric surgery - 1 Jul 2008

Ruiz-Ferrer Macarena, Fernandez Raquel M, Antiñolo Guillermo, Lopez-Alonso Manuel, Borrego Salud

Abstract excerpt

Hirschsprung disease (HSCR) is a congenital disorder caused by a failure of neural crest cells to migrate, proliferate, and/or differentiate during the enteric nervous system (ENS) development. The requirement of the NTF-3/TrkC signaling for the proper development of the ENS, together with the evidences presented by animal models, led us to investigate the involvement of NTF-3 gene in HSCR. We performed both a...

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Identifiers

PMID: 18639687
DOI: 10.1016/j.jpedsurg.2008.02.076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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