Article
Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease.
Experimental and molecular pathology - 1 Oct 2016
Su Lin, Zhang Zhen, Gan Liang, Jiang Qian, Xiao Ping, Zou Jizhen, Li Qi, Jiang Hong
Abstract excerpt
Hirschsprung disease (HSCR) is a congenital disorder characterized by the absence of intrinsic ganglion cells in the lower intestine. Genetic factors in the pathogenesis of this disease are under active investigation. As core genes in the planar cell polarity pathway, Celsr3 and Fzd3 are believed to play vital roles in the development of the murine enteric nervous system. The potential association of CELSR3 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.