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Article

Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease.

Journal of pediatric surgery - 1 Nov 2008

Fernandez Raquel M, Ruiz-Ferrer Macarena, Lopez-Alonso Manuel, Antiñolo Guillermo, Borrego Salud

Abstract excerpt

PURPOSE: Hirschsprung disease (HSCR) is a developmental disorder caused by a failure of neural crest cells to migrate, proliferate, and/or differentiate during the enteric nervous system development. It presents a multifactorial, nonmendelian pattern of inheritance, with several genes playing som...

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Source

Identifiers

PMID: 18970938
DOI: 10.1016/j.jpedsurg.2008.05.018

Genes

RET
ARTN
GDNF
PSPN
NRTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18970938-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease.PMID 18970938Read ↗

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Functional haplotypes of the RET proto-oncogene promoter are associated with Hirschsprung disease (HSCR)Semantic proximity Read ↗

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