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Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer

20 Jan 2018

Abstract excerpt

DNA damage response and repair genes (DDR genes) are commonly mutated in bladder cancer. The biological impact of these mutations is an area of intense basic, translational, and clinical interest. As next generation sequencing increases its foothold in the treatment of localized and advanced bladder cancer, the role of DDR genes will continue to evolve. We review the inventory and biology of DDR genes in bladder...

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PMID: 29430503
DOI: 10.3233/blc-170129

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