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Article

TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7.

FEBS letters - 22 May 2015

Wang Yanming, Yan Shanshan, Yang Bo, Wang Yan, Zhou Haiyan, Lian Qiaoshi, Sun Bing

Abstract excerpt

Toll-like receptor 7 (TLR7) and TLR9 sense viral nucleic acids and induce type I IFN production, which must be properly controlled to avoid autoimmune diseases. Here, we report the negative regulation of TLR7/9-mediated type I IFN production by TRIM35. TRIM35 expression is induced by TLR7/9 stimulation and then interacts with IRF7, which is the master regulator of type I IFN response. Furthermore, TRIM35 promotes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25907537
DOI: 10.1016/j.febslet.2015.04.019

Genes

TLR7
TRIM35
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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