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Article

Genetic predictors of MEK dependence in non-small cell lung cancer.

Cancer research - 15 Nov 2008

Pratilas Christine A, Hanrahan Aphrothiti J, Halilovic Ensar, Persaud Yogindra, Soh Junichi, Chitale Dhananjay, Shigematsu Hisayuki, Yamamoto Hiromasa, Sawai Ayana, Janakiraman Manickam, Taylor Barry S, Pao William, Toyooka Shinichi, Ladanyi Marc, Gazdar Adi, Rosen Neal, Solit David B

Abstract excerpt

Hyperactivated extracellular signal-regulated kinase (ERK) signaling is common in human cancer and is often the result of activating mutations in BRAF, RAS, and upstream receptor tyrosine kinases. To characterize the mitogen-activated protein kinase/ERK kinase (MEK)/ERK dependence of lung cancers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19010912
DOI: 10.1158/0008-5472.CAN-08-2223
PMCID: PMC2649746

Genes

BRAF
EGFR
KRAS
ALK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19010912-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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