Article
Does folic acid supplementation prevent or promote colorectal cancer? Results from model-based predictions.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2008
Luebeck E Georg, Moolgavkar Suresh H, Liu Amy Y, Boynton Alanna, Ulrich Cornelia M
Abstract excerpt
Folate is essential for nucleotide synthesis, DNA replication, and methyl group supply. Low-folate status has been associated with increased risks of several cancer types, suggesting a chemopreventive role of folate. However, recent findings on giving folic acid to patients with a history of colorectal polyps raise concerns about the efficacy and safety of folate supplementation and the long-term health effects...
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