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Article

Activation of the cholinergic anti-inflammatory system by nicotine attenuates arthritis via suppression of macrophage migration.

Molecular medicine reports - 1 Dec 2016

Li Sha, Zhou Bin, Liu Ben, Zhou Yaou, Zhang Huali, Li Tong, Zuo Xiaoxia

Abstract excerpt

Activation of the cholinergic anti-inflammatory pathway (CAP), which relies on the alpha-7 nicotinic acetylcholine receptor, has been reported to reduce proinflammatory cytokine levels in experimental arthritis. To gain more insight regarding the role of the CAP in the pathogenesis of arthritis, the present study focused on the modulation of macrophage infiltration. In a mouse model of collagen‑induced arthritis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27840928
DOI: 10.3892/mmr.2016.5904
PMCID: PMC5355730

Genes

MIP
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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