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Article

The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotype.

Journal of cellular and molecular medicine - 1 Jul 2009

Frey Benjamin, Munoz Luis E, Pausch Friederike, Sieber Renate, Franz Sandra, Brachvogel Bent, Poschl Ernst, Schneider Holm, Rödel Franz, Sauer Rolf, Fietkau Rainer, Herrmann Martin, Gaipl Udo S

Abstract excerpt

Proteins of the annexin family bind to phospholipids in a Ca(2+) dependent manner. The exposure of phosphatidylserine (PS) by apoptotic as well as necrotic cells is one major eat-me-signal for macrophages. Annexin A5 (Anx A5) preferentially binds to PS. The availability of Anx A5 knock out (KO) mice allowed us to investigate for the first time if endogenous Anx A5 modulates the immune response towards allogeneic...

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Identifiers

PMID: 18624762
DOI: 10.1111/j.1582-4934.2008.00395.x
PMCID: PMC4496152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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