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Article

Deficiency of the cystine-transporter gene, xCT, does not exacerbate the deleterious phenotypic consequences of SOD1 knockout in mice.

Molecular and cellular biochemistry - 1 Dec 2008

Iuchi Yoshihito, Kibe Noriko, Tsunoda Satoshi, Okada Futoshi, Bannai Shiro, Sato Hideyo, Fujii Junichi

Abstract excerpt

Because glutathione scavenges reactive oxygen species (ROS) and also donates electrons to antioxidative systems, it may compensate for the oxidative stress caused by SOD1 deficiency. The cystine/glutamate transporter, which consists of two proteins, xCT and 4F2hc, has been designated system x (c) (-) . This transporter system plays a role in the maintenance of glutathione levels in mammalian cells. In the present...

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Source

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PMID: 18622736
DOI: 10.1007/s11010-008-9885-3

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deficiency of the cystine-transporter gene, xCT, does not exacerbate the deleterious phenotypic consequences of SOD1 knockout in mice.PMID 18622736Read ↗

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