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Article

Dysregulation of system xc(-) expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice.

Neurochemistry international - 1 Oct 2014

Frederick Natalie M, Bertho Julie, Patel Kishan K, Petr Geraldine T, Bakradze Ekaterina, Smith Sylvia B, Rosenberg Paul A

Abstract excerpt

Oxidative stress has been implicated in the pathogenesis of Huntington's disease (HD), however, the origin of the oxidative stress is unknown. System xc(-) plays a role in the import of cystine to synthesize the antioxidant glutathione. We found in the STHdh(Q7/Q7) and STHdh(Q111/Q111) striatal cell lines, derived from neuronal precursor cells isolated from knock-in mice containing 7 or 111 CAG repeats in the...

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Identifiers

PMID: 25004085
DOI: 10.1016/j.neuint.2014.06.017
PMCID: PMC4186714

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