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Article

Testis-Specific Cytochrome <i>c</i>-Null Mice Produce Functional Sperm but Undergo Early Testicular Atrophy

28 Jul 2002

Abstract excerpt

Differentiating male germ cells express a testis-specific form of cytochrome c (Cyt c(T)) that is distinct from the cytochrome c expressed in somatic cells (Cyt c(S)). To examine the role of Cyt c(T) in germ cells, we generated mice null for Cyt c(T). Homozygous Cyt c(T)(-/-) pups were statistically underrepresented (21%) but developed normally and were fertile. However, spermatozoa isolated from the cauda...

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Identifiers

PMID: 12101247
DOI: 10.1128/mcb.22.15.5554-5562.2002

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