Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C-reactive protein and vein graft disease: evidence for a direct effect on smooth muscle cell phenotype via modulation of PDGF receptor-beta.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2008

Ho Karen J, Owens Christopher D, Longo Thomas, Sui Xin X, Ifantides Cristos, Conte Michael S

Abstract excerpt

Plasma C-reactive protein (CRP) concentration is a biomarker of systemic atherosclerosis and may also be associated with vein graft disease. It remains unclear whether CRP is also an important modulator of biological events in the vessel wall. We hypothesized that CRP influences vein graft healing by stimulating smooth muscle cells (SMCs) to undergo a phenotypic switch. Distribution of CRP was examined by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Vessels
Share to C-Reactive Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemotaxis

Share to Elastin

Share to Image Processing, Computer-Assisted

Share to Myocytes, Smooth Muscle

Share to Receptor, Platelet-Derived Growth Factor beta

Share to Transplantation, Autologous

Source

Open in PubMed Open full text

Identifiers

PMID: 18621860
DOI: 10.1152/ajpheart.00079.2008
PMCID: PMC2544486

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C-reactive protein and vein graft disease: evidence for a direct effect on smooth muscle cell phenotype via modulation of PDGF receptor-beta.PMID 18621860Read ↗

C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expressionSemantic proximity Read ↗

Role of smooth muscle cells in coronary artery bypass grafting failure.Semantic proximity Read ↗

PDGF and cardiovascular diseaseSemantic proximity Read ↗

Modulation of cysteine-rich protein 2 expression in vascular injury and atherosclerosis.Semantic proximity Read ↗

Association of smooth muscle cell phenotypic modulation with extracellular matrix alterations during neointima formation in rabbit vein grafts.Semantic proximity Read ↗

G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development.Semantic proximity Read ↗

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta.Semantic proximity Read ↗

Immunohistochemical phenotypic alterations of rabbit autologous vein grafts implanted under arterial circulation with or without poor distal runoff-implications of vein graft remodeling.Semantic proximity Read ↗

Remodeling of autologous saphenous vein grafts. The role of perivascular myofibroblasts.Semantic proximity Read ↗

Altered fibronectin-dependent cell adhesion by PDGF accompanies phenotypic modulation of vascular smooth muscle cells.Semantic proximity Read ↗

The modulation of smooth muscle cell phenotype is an early event in human aorto-coronary saphenous vein grafts.Semantic proximity Read ↗

Arterial heparan sulfate proteoglycans inhibit vascular smooth muscle cell proliferation and phenotype change in vitro and neointimal formation in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.