Article
G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 1998
Davies M G, Huynh T T, Fulton G J, Lefkowitz R J, Svendsen E, Hagen P O, Koch W J
Abstract excerpt
Vein grafting results in the development of intimal hyperplasia with accompanying changes in guanine nucleotide-binding (G) protein expression and function. Several serum mitogens that act through G protein-coupled receptors, such as lysophosphatidic acid, stimulate proliferative pathways that ar...
Topics
- Analysis of Variance
- Animals
- Base Sequence
- Cyclic AMP-Dependent Protein Kinases
- GTP-Binding Proteins
- Gene Expression Regulation, Enzymologic
- Gene Transfer Techniques
- Hyperplasia
- Microscopy, Electron, Scanning
- Molecular Sequence Data
- Peptide Fragments
- Phenotype