The prognostic implication of the basal-like (cyclin E high/p27 low/p53+/glomeruloid-microvascular-proliferation+) phenotype of BRCA1-related breast cancer.

doi:10.1158/0008-5472.can-03-2970

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The prognostic implication of the basal-like (cyclin E high/p27 low/p53+/glomeruloid-microvascular-proliferation+) phenotype of BRCA1-related breast cancer.

Cancer research - 1 Feb 2004

Foulkes William D, Brunet Jean-Sébastien, Stefansson Ingunn M, Straume Oddbjørn, Chappuis Pierre O, Bégin Louis R, Hamel Nancy, Goffin John R, Wong Nora, Trudel Michel, Kapusta Linda, Porter Peggy, Akslen Lars A

Abstract excerpt

Previous studies have shown that BRCA1-related breast cancers are often high-grade tumors that do not express estrogen receptors, HER2, p27(Kip1), or cyclin D1, but do express p53 and cyclin E. In addition, the expression of cytokeratin 5/6 (CK5/6), indicating a basal epithelial phenotype, is frequent in BRCA1-related breast cancer. Here, in a series of 247 breast cancers, we demonstrate that CK5/6 expression was...

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The prognostic implication of the basal-like (cyclin E high/p27 low/p53+/glomeruloid-microvascular-proliferation+) phenotype of BRCA1-related breast cancer.

Abstract excerpt

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