Article
Preclinical Serological Signatures are Associated With Complicated Crohn's Disease Phenotype at Diagnosis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Oct 2023
Choung Rok Seon, Petralia Francesca, Torres Joana, Ungaro Ryan C, Porter Chad, Sato Takahiro, Telesco Shannon, Strauss Richard S, Plevy Scott, Princen Fred, Riddle Mark S, Murray Joseph A, Colombel Jean Frederic
Abstract excerpt
BACKGROUND: At diagnosis, up to one-third of patients with Crohn's disease (CD) have a complicated phenotype with stricturing (B2) or penetrating (B3) behavior or require early surgery. We evaluated protein biomarkers and antimicrobial antibodies in serum archived years before CD diagnosis to assess whether complicated diagnoses were associated with a specific serological signature. METHODS: Prediagnosis serum...
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