Article
Antibodies to saccharomyces cerevisiae in Crohn's disease: higher titers are associated with a greater frequency of mutant NOD2/CARD15 alleles and with a higher probability of complicated disease.
Inflammatory bowel diseases - 1 Feb 2007
Dassopoulos Themistocles, Frangakis Constantine, Cruz-Correa Marcia, Talor Monica V, Burek C Lynne, Datta Lisa, Nouvet Franklin, Bayless Theodore M, Brant Steven R
Abstract excerpt
BACKGROUND: Both antibodies to Saccharomyces cerevisiae (ASCA) and carriage of two mutated NOD2/CARD15 alleles are associated with ileal Crohn's disease (CD) and complications requiring bowel surgery. We assessed the ASCA titer as a marker of CD clinical behavior. METHODS: In a cross-sectional study, we phenotyped 117 unrelated CD patients. Titers (Units, U) of ASCA IgG and IgA were measured and patients were...
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