Article
Impaired performance of FDR-based strategies in whole-genome association studies when SNPs are excluded prior to the analysis.
Genetic epidemiology - 1 Jan 2009
Marenne Gaëlle, Dalmasso Cyril, Perdry Hervé, Génin Emmanuelle, Broët Philippe
Abstract excerpt
With recent advances in genomewide microarray technologies, whole-genome association (WGA) studies have aimed at identifying susceptibility genes for complex human diseases using hundreds of thousands of single nucleotide polymorphisms (SNPs) genotyped at the same time. In this context and to take into account multiple testing, false discovery rate (FDR)-based strategies are now used frequently. However, a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.