Article
Stratified false discovery control for large-scale hypothesis testing with application to genome-wide association studies.
Genetic epidemiology - 1 Sept 2006
Sun Lei, Craiu Radu V, Paterson Andrew D, Bull Shelley B
Abstract excerpt
The multiplicity problem has become increasingly important in genetic studies as the capacity for high-throughput genotyping has increased. The control of False Discovery Rate (FDR) (Benjamini and Hochberg. [1995] J. R. Stat. Soc. Ser. B 57:289-300) has been adopted to address the problems of false positive control and low power inherent in high-volume genome-wide linkage and association studies. In many genetic...
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