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Article

Genetic polymorphisms in oestrogen metabolic pathway and breast cancer: a positive association with combined CYP/GST genotypes.

Clinical and experimental medicine - 1 Jun 2008

Torresan C, Oliveira M M C, Torrezan G T, de Oliveira S F V, Abuázar C S, Losi-Guembarovski R, Lima R S, Urban C A, Cavalli I J, Ribeiro E M S F

Abstract excerpt

The cytochrome P450 family (CYPs) and the glutathione S-transferase (GSTs) enzymes play an important role in the metabolism of environmental carcinogens and of oestrogen and can affect breast cancer risk. In this study we examine the role of the genes CYP1A1, CYP17, CYP2D6, GSTM1, GSTP1 and GSTT1 in breast cancer risk in Brazilian women. The study population consisted of 102 incident breast cancer cases and 102...

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Source

Identifiers

PMID: 18618215
DOI: 10.1007/s10238-008-0159-x

Genes

GSTP1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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