Discovery and mechanism of action of pegvisomant

Abstract excerpt

Using a structure-function approach to the understanding of the molecular topology of the GH molecule, we discovered that glycine in the third alpha-helix of GH (G119 of bovine GH and G120 of human GH) was an important amino acid required for GH action. Substitution of this glycine residue with a variety of amino acids results in molecules that lack growth-promoting activity. More importantly, these molecules...

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