Article
A growth hormone receptor mutation impairs growth hormone autofeedback signaling in pituitary tumors.
Cancer research - 1 Aug 2007
Asa Sylvia L, Digiovanni Rebecca, Jiang Jing, Ward Megan L, Loesch Kimberly, Yamada Shozo, Sano Toshiaki, Yoshimoto Katsuhiko, Frank Stuart J, Ezzat Shereen
Abstract excerpt
Pituitary tumors are a diverse group of neoplasms that are classified based on clinical manifestations, hormone excess, and histomorphologic features. Those that cause growth hormone (GH) excess and acromegaly are subdivided into morphologic variants that have not yet been shown to have pathogenetic significance or predictive value for therapy and outcome. Here, we identify a selective somatic...
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