Article
Multimarker analysis and imputation of multiple platform pooling-based genome-wide association studies.
Bioinformatics (Oxford, England) - 1 Sept 2008
Homer Nils, Tembe Waibhav D, Szelinger Szabolcs, Redman Margot, Stephan Dietrich A, Pearson John V, Nelson Stanley F, Craig David
Abstract excerpt
For many genome-wide association (GWA) studies individually genotyping one million or more SNPs provides a marginal increase in coverage at a substantial cost. Much of the information gained is redundant due to the correlation structure inherent in the human genome. Pooling-based GWA studies could benefit significantly by utilizing this redundancy to reduce noise, improve the accuracy of the observations and...
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