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Development of a new assay for evaluation of l-3,4-dihydroxyphenylalanine cytotoxicity in catalase-mutant Escherichia coli.

Environmental toxicology and chemistry - 1 Aug 2008

Wang Da-Hong, Horita Masako, Tsutsui Ken, Sano Kuniaki, Sauriasari Rani, Masuoka Noriyoshi, Takemura Yoko, Takigawa Tomoko, Takaki Jiro, Ogino Keiki

Abstract excerpt

The present study aimed to assess whether a newly constructed, catalase-deficient Escherichia coli strain that express mammalian catalase gene could be used to identify oxidative stress-generating chemicals. We tested l-3,4-dihydroxyphenylalanine (l-DOPA), a well-known agent that induces reactive oxygen species. We found that l-DOPA exposure reduced the survival of catalase-mutant E. coli in a dose-dependent...

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PMID: 18616383
DOI: 10.1897/07-617.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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