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Article

Nitric oxide promotes strong cytotoxicity of phenolic compounds against Escherichia coli: the influence of antioxidant defenses.

Free radical biology & medicine - 1 Dec 2003

Urios Amparo, López-Gresa M Pilar, González M Carmen, Primo Jaime, Martínez Alicia, Herrera Guadalupe, Escudero Juan C, O'Connor José-Enrique, Blanco Manuel

Abstract excerpt

The induction of mutagenic and cytotoxic effects by simple phenolics, including catechol (CAT), 3,4-dihydroxyphenylacetic acid (DOPAC), hydroquinone (HQ), and 2,5-dihydroxyphenylacetic (homogentisic) acid (HGA), appears to occur through an oxidative mechanism based on the ability of these compounds to undergo autoxidation, leading to quinone formation with the production of reactive oxygen species. This is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 14642385
DOI: 10.1016/j.freeradbiomed.2003.08.007

Genes

MCAT
CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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