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Article

Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia.

Journal of enzyme inhibition and medicinal chemistry - 1 Dec 2008

Iwana Sanae, Kawazoe Tomoya, Park Hwan Ki, Tsuchiya Koichiro, Ono Koji, Yorita Kazuko, Sakai Takashi, Kusumi Takenori, Fukui Kiyoshi

Abstract excerpt

D-amino acid oxidase (DAO), a potential risk factor for schizophrenia, has been proposed to be involved in the decreased glutamatergic neurotransmission in schizophrenia. Here we show the inhibitory effect of an antipsychotic drug, chlorpromazine, on human DAO, which is consistent with previous reports using porcine DAO, although human DAO was inhibited to a lesser degree (K(i) = 0.7 mM) than porcine DAO. Since...

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PMID: 18615285
DOI: 10.1080/14756360701745478

Genes

DAO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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