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Article

Photomutagenicity of chlorpromazine and its N-demethylated metabolites assessed by NGS.

Scientific reports - 23 Apr 2020

Agúndez José A G, García-Martín Elena, García-Lainez Guillermo, Miranda Miguel A, Andreu Inmaculada

Abstract excerpt

The human genome is constantly attacked by endogenous and exogenous agents (ultraviolet light, xenobiotics, reactive oxygen species), which can induce chemical transformations leading to DNA lesions. To combat DNA damage, cells have developed several repair mechanisms; however, if the repair is defective, DNA lesions lead to permanent mutations. Single-cell gel electrophoresis (COMET assay) is a sensitive and...

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Identifiers

PMID: 32327675
DOI: 10.1038/s41598-020-63651-y
PMCID: PMC7181754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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