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Article

Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon.

Biochemical pharmacology - 1 Aug 1998

Amitai G, Moorad D, Adani R, Doctor B P

Abstract excerpt

Phosphorothionate insecticides such as parathion (O,O-diethyl O-p-nitrophenyl phosphorothioate) and chlorpyrifos (CPS; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate; Dursban) are metabolically converted by oxidative desulfuration into paraoxon and chlorpyrifos-oxon (CPO). The insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (AChE) by CPO, resulting in severe cholinergic...

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Source

Identifiers

PMID: 9744565
DOI: 10.1016/s0006-2952(98)00035-5

Genes

CPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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