Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon.

doi:10.1016/s0006-2952(98)00035-5

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Article

Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon.

Biochemical pharmacology - 1 Aug 1998

Amitai G, Moorad D, Adani R, Doctor B P

Abstract excerpt

Phosphorothionate insecticides such as parathion (O,O-diethyl O-p-nitrophenyl phosphorothioate) and chlorpyrifos (CPS; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate; Dursban) are metabolically converted by oxidative desulfuration into paraoxon and chlorpyrifos-oxon (CPO). The insectici...

Topics

Acetylcholinesterase
Animals
Butyrylcholinesterase
Chlorpyrifos
Cholinesterase Inhibitors
Humans
Insecticides
Kinetics
Mice
Mutation
Paraoxon

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