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Article

Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients.

Scientific reports - 21 May 2020

Davies Andrea, Rodriguez-Vicente Ana Eugenia, Austin Gemma, Loaiza Sandra, Foroni Letizia, Clark Richard E, Pirmohamed Munir

Abstract excerpt

Tyrosine kinase inhibitors (TKIs), the treatment of choice for chronic myeloid leukaemia (CML), can cause lower gastrointestinal (GI) toxicity which is manifested as diarrhoea. The mechanisms are not fully understood. The enteroendocrine signalling compound, serotonin (5-HT), is important for regulating peristaltic motion, fluid secretion and visceral hypersensitivity in the GI tract, and has been implicated in...

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Identifiers

PMID: 32439979
DOI: 10.1038/s41598-020-65350-0
PMCID: PMC7242433

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