Article
Inflammatory gene haplotype-interaction networks involved in coronary collateral formation.
Human heredity - 1 Jan 2008
Zhang Jian, Regieli Jakub J, Schipper Maria, Entius Mark M, Liang Faming, Koerselman Jeroen, Ruven Hendrik J T, van der Graaf Yolanda, Grobbee Diederick E, Doevendans Pieter A
Abstract excerpt
OBJECTIVES: Formation of collateral circulation is an endogenous response to atherosclerosis, and is a natural escape mechanism by re-routing blood. Inflammatory response- related genes underlie the formation of coronary collaterals. We explored the genetic basis of collateral formation in man postulating interaction networks between functional Single Nucleotide Polymorphisms (SNPs) in these inflammatory gene...
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