Article
Identification of a novel 120 bp allele at the TNFd microsatellite locus.
Tissue antigens - 1 Apr 2006
Wastowski I J, Peres N T A, Simões R T, Castelli E C, Simões A L, Martinez-Rossi N M, Donadi E A
Abstract excerpt
Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine mainly secreted by macrophages and T-cells that play a key role in the pathogenesis of many infectious and inflammatory diseases. The TNF gene cluster is located within the class-III region of the highly polymorphic major histocompatibility complex on human chromosome 6p21. A cluster of six multiallelic microsatellites has been identified in...
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