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Article

Structure and membrane topology of TAPA-1.

The Journal of biological chemistry - 5 Aug 1991

Levy S, Nguyen V Q, Andria M L, Takahashi S

Abstract excerpt

TAPA-1 (the target of an antiproliferative antibody) is a 26-kDa cell surface protein expressed on most human cell lines. TAPA-1 is a member of an evolutionarily related family of cell surface proteins all of which contain four transmembrane domains. A model is proposed for topology of TAPA-1 based on proteolysis studies in the in vitro translated protein embedded into microsomal membranes. This analysis predicts...

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PMID: 1860863

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