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Article

Comparison of multivariate adaptive regression splines and logistic regression in detecting SNP-SNP interactions and their application in prostate cancer.

Journal of human genetics - 1 Jan 2008

Lin Hui-Yi, Wang Wenquan, Liu Yung-Hsin, Soong Seng-Jaw, York Timothy P, Myers Leann, Hu Jennifer J

Abstract excerpt

Single nucleotide polymorphism (SNP) interaction plays a critical role for complex diseases. The primary limitation of logistic regressions (LR) in testing SNP-SNP interactions is that coefficient estimates may not be valid because of numerous terms in a model. Multivariate adaptive regression splines (MARS) have useful features to effectively reduce the number of terms in a model. To study how MARS can address...

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PMID: 18607530
DOI: 10.1007/s10038-008-0313-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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