Article
SNP interaction pattern identifier (SIPI): an intensive search for SNP-SNP interaction patterns.
Bioinformatics (Oxford, England) - 15 Mar 2017
Lin Hui-Yi, Chen Dung-Tsa, Huang Po-Yu, Liu Yung-Hsin, Ochoa Augusto, Zabaleta Jovanny, Mercante Donald E, Fang Zhide, Sellers Thomas A, Pow-Sang Julio M, Cheng Chia-Ho, Eeles Rosalind, Easton Doug, Kote-Jarai Zsofia, Amin Al Olama Ali, Benlloch Sara, Muir Kenneth, Giles Graham G, Wiklund Fredrik, Gronberg Henrik, Haiman Christopher A, Schleutker Johanna, Nordestgaard Børge G, Travis Ruth C, Hamdy Freddie, Pashayan Nora, Khaw Kay-Tee, Stanford Janet L, Blot William J, Thibodeau Stephen N, Maier Christiane, Kibel Adam S, Cybulski Cezary, Cannon-Albright Lisa, Brenner Hermann, Kaneva Radka, Batra Jyotsna, Teixeira Manuel R, Pandha Hardev, Lu Yong-Jie, Park Jong Y
Abstract excerpt
Motivation: Testing SNP-SNP interactions is considered as a key for overcoming bottlenecks of genetic association studies. However, related statistical methods for testing SNP-SNP interactions are underdeveloped. Results: We propose the SNP Interaction Pattern Identifier (SIPI), which tests 45 biologically meaningful interaction patterns for a binary outcome. SIPI takes non-hierarchical models, inheritance modes...
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