Multiple single nucleotide polymorphism analysis using penalized regression in nonlinear mixed-effect pharmacokinetic models.

doi:10.1097/FPC.0b013e32835dd22c

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Article

Multiple single nucleotide polymorphism analysis using penalized regression in nonlinear mixed-effect pharmacokinetic models.

Pharmacogenetics and genomics - 1 Mar 2013

Bertrand Julie, Balding David J

Abstract excerpt

CONTEXT: Studies on the influence of single nucleotide polymorphisms (SNPs) on drug pharmacokinetics (PK) have usually been limited to the analysis of observed drug concentration or area under the concentration versus time curve. Nonlinear mixed effects models enable analysis of the entire curve, even for sparse data, but until recently, there has been no systematic method to examine the effects of multiple SNPs...

Topics

Algorithms
Humans
Pharmacokinetics
Polymorphism, Single Nucleotide
Regression Analysis

Source

Open in PubMed

Identifiers

PMID: 23337849
DOI: 10.1097/FPC.0b013e32835dd22c

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