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Article

Characterisation of novel defective thiopurine S-methyltransferase allelic variants.

Biochemical pharmacology - 1 Aug 2008

Garat A, Cauffiez C, Renault N, Lo-Guidice J M, Allorge D, Chevalier D, Houdret N, Chavatte P, Loriot M A, Gala J L, Broly F

Abstract excerpt

Human thiopurine S-methyltransferase (TPMT, EC 2.1.1.67) is a key enzyme in the detoxification of thiopurine drugs widely used in the treatment of various diseases, such as inflammatory bowel diseases, acute lymphoblastic leukaemia and rheumatic diseases. The TPMT gene is genetically polymorphic and the inverse relationship between TPMT activity and the risk of developing severe hematopoietic toxicity is well...

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Source

Identifiers

PMID: 18602085
DOI: 10.1016/j.bcp.2008.05.009

Genes

TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Characterisation of novel defective thiopurine S-methyltransferase allelic variants.PMID 18602085Read ↗

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Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics.Semantic proximity Read ↗

Nomenclature for alleles of the thiopurine methyltransferase gene.Semantic proximity Read ↗

Identification of rare defective allelic variants in cases of thiopurine S-methyltransferase deficient activity.Semantic proximity Read ↗

Three novel thiopurine S-methyltransferase allelic variants (TPMT*20, *21, *22) - association with decreased enzyme function.Semantic proximity Read ↗

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Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5.Semantic proximity Read ↗

Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2 - *24).Semantic proximity Read ↗

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