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Article

Connective tissue growth factor inhibits adipocyte differentiation.

American journal of physiology. Cell physiology - 1 Sept 2008

Tan Joanne T M, McLennan Susan V, Song William W, Lo Lisa W-Y, Bonner James G, Williams Paul F, Twigg Stephen M

Abstract excerpt

Adipocyte differentiation is a key process implicated in the pathogenesis of obesity and insulin resistance. Its regulation is triggered by a cascade of transcription factors, including the CCAAT/enhancer binding proteins (C/EBPs) and peroxisome proliferator-activated receptor-gamma (PPARgamma). Growth factors such as transforming growth factor-beta1 (TGF-beta1) are known to inhibit adipocyte differentiation in...

Topics

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Adipocytes
Adipogenesis
Autocrine Communication
CCAAT-Enhancer-Binding Protein-alpha
CCAAT-Enhancer-Binding Protein-beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Connective Tissue Growth Factor

Glycerolphosphate Dehydrogenase

Immediate-Early Proteins

Source

Identifiers

PMID: 18596209
DOI: 10.1152/ajpcell.00333.2007

Genes

EBP
CCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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