Article
Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP).
The Journal of clinical investigation - 1 Jan 1992
Ron D, Brasier A R, McGehee R E, Habener J F
Abstract excerpt
Tumor necrosis factor (TNF)-treated 3T3-L1 adipocytes were used as a model for studying the effects of systemic inflammation on adipose tissue. Lipopolysaccharide-treated monocyte-conditioned medium or recombinant human TNF alpha induced morphological dedifferentiation of the adipocytes and led t...
Topics
- 3T3 Cells
- Acute-Phase Reaction
- Adipose Tissue
- Animals
- Base Sequence
- CCAAT-Enhancer-Binding Proteins
- Cell Differentiation
- Cell Nucleus
- Cytokines
- DNA-Binding Proteins
- Mice
- Molecular Sequence Data
- Phenotype
- Transcription Factors
- Tumor Necrosis Factor-alpha