Article
Tumor necrosis factor-alpha and basic fibroblast growth factor differentially inhibit the insulin-like growth factor-I induced expression of myogenin in C2C12 myoblasts.
Experimental cell research - 25 May 1999
Layne M D, Farmer S R
Abstract excerpt
Tumor necrosis factor-alpha (TNF-alpha) plays a role in several disease states such as sepsis, cachexia, and non-insulin-dependent diabetes. TNF-alpha interferes with insulin signaling and inhibits differentiation-specific gene expression in adipose tissue and skeletal muscle. We have examined the mechanisms by which TNF-alpha, in comparison to basic fibroblast growth factor (bFGF), inhibits the insulin-like...
Topics
- Animals
- Cell Adhesion
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Collagen
- Depression, Chemical
- Fibroblast Growth Factor 2
- Gene Expression Regulation
- Insulin-Like Growth Factor I
- Mice
- Muscle, Skeletal
- Myogenin
- Phenotype
- Transcription, Genetic
- Tumor Necrosis Factor-alpha