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Article

The Forkhead Transcription Factor FoxC2 Inhibits White Adipocyte Differentiation

24 Jul 2004

Abstract excerpt

In this study, we show that expression of FoxC2 blocks the capacity of 3T3-L1 preadipocytes to undergo adipogenesis in the presence of dexamethasone, isobutylmethylxanthine, and insulin. This block is characterized by an extensive decrease in the expression of proteins associated with the function of the mature fat cell, most notably C/EBPalpha, adiponectin, perilipin, and the adipose-specific fatty acid-binding...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 15277530
DOI: 10.1074/jbc.m402197200

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