Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combinatorial Signals of Activin/Nodal and Bone Morphogenic Protein Regulate the Early Lineage Segregation of Human Embryonic Stem Cells

3 Jul 2008

Abstract excerpt

Cell fate commitment of pre-implantation blastocysts, to either the inner cell mass or trophoblast, is the first step in cell lineage segregation of the developing human embryo. However, the intercellular signals that control fate determination of these cells remain obscure. Human embryonic stem cells (hESCs) provide a unique model for studying human early embryonic development. We have previously shown that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pluripotent Stem Cells Research
Share to Renal and related cancers
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18596037
DOI: 10.1074/jbc.m803893200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combinatorial Signals of Activin/Nodal and Bone Morphogenic Protein Regulate the Early Lineage Segregation of Human Embryonic Stem CellsPMID 18596037Read ↗

Activin/Nodal Signaling Switches the Terminal Fate of Human Embryonic Stem Cell-derived TrophoblastsSemantic proximity Read ↗

Deciphering transcriptional regulation in human embryonic stem cells specified towards a trophoblast fateSemantic proximity Read ↗

Revisiting trophectoderm-inner cell mass lineage segregation in the mammalian preimplantation embryoSemantic proximity Read ↗

Totipotency and lineage segregation in the human embryoSemantic proximity Read ↗

Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signalingSemantic proximity Read ↗

Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4Semantic proximity Read ↗

Endogenous WNT signals mediate BMP-induced and spontaneous differentiation of epiblast stem cells and human embryonic stem cells.Semantic proximity Read ↗

BMP4 initiates human embryonic stem cell differentiation to trophoblastSemantic proximity Read ↗

Specification of trophoblast from embryonic stem cells exposed to BMP4†Semantic proximity Read ↗

Human hypoblast formation is not dependent on FGF signallingSemantic proximity Read ↗

TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cellsSemantic proximity Read ↗

Evidence implicating sequential commitment of the founder lineages in the human blastocyst by order of hypoblast gene activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.