Reduction of genotoxic effects of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine by dietary lignin in mammalian cells cultured in vitro.

doi:10.1207/s15327914nc4701_12

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Article

Reduction of genotoxic effects of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine by dietary lignin in mammalian cells cultured in vitro.

Nutrition and cancer - 1 Jan 2003

Lábaj Juraj, Slamenová Darina, Kosikova Bozena

Abstract excerpt

In the present study the protective effect of several lignin polymers against the genotoxic effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was tested in hamster lung V79 cells and human colon Caco-2 cells. Preculturing of cells with sublethal, nongenotoxic concentrations of the lignins A, B, and C (50 microg/ml) was found to decrease significantly the level of DNA strand breaks in both hamster and human...

Topics

Animals
Caco-2 Cells
Carcinogens
Cell Line
Cricetinae
DNA
DNA Damage
DNA Repair
Diet
Humans
Lignin
Lung
Methylnitronitrosoguanidine
Mutation
Oxidative Stress

Source

Open in PubMed

Identifiers

PMID: 14769543
DOI: 10.1207/s15327914nc4701_12

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