Article
Endothelium-induced proliferation and electrophysiological differentiation of human embryonic stem cell-derived neuronal precursors.
Stem cells and development - 1 Jun 2008
Lai Bin, Mao Xiao Ou, Greenberg David A, Jin Kunlin
Abstract excerpt
Neurogenesis occurs in a stem cell niche in which vascular elements, including endothelial cells (ECs), are thought to play an important role. Using co-culture experiments, we investigated the effect of ECs on proliferation and functional neuronal differentiation of human embryonic stem (ES) cellderived neuronal precursor cells (NPCs). NPCs were cultured for 5 days in medium containing fibroblast growth factor-2...
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